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bonesetAlso Known As:

Agueweed, Crosswort, Eupatoire, Eupatorio, Feverwort, Indian Sage, Sweating
Plant, Teasel, Thoroughwort, Vegetable Antimony.
CAUTION: See separate listings for Gravel Root and Sage.

Scientific Name:

Eupatorium perfoliatum.

Family: Asteraceae/Compositae.

People Use This For:

Orally, boneset is used as an antipyretic, diuretic, laxative, emesis, and cathartic.
Boneset is also used to treat influenza (especially with aching muscles), swine
flu, acute bronchitis, nasal inflammation, rheumatism, edema, dengue fever, and
pneumonia; and as a stimulant and a diaphoretic.


POSSIBLY UNSAFE: When used orally in excessive amounts. Large doses are

both cathartic and emetic. Though the alkaloids have not been characterized,

hepatotoxic pyrrolizidine alkaloids (PAs) are common in this genus (3).


to possible hepatotoxic pyrrolizidine alkaloid content (3); avoid using.


There is insufficient reliable information available about the effectiveness of


Mechanism of Action:

The applicable parts of boneset are the dried leaf and flowering parts.

Preliminary research suggests boneset might have cytotoxic and mild

antibacterial activity (4).

Adverse Reactions:

Report an Adverse Reaction to BONESET

Orally, boneset can cause an allergic reaction in individuals sensitive to the

Asteraceae / Compositae family. Members of this family include ragweed,

chrysanthemums, marigolds, daisies, and many other herbs.

Interactions with Herbs & Supplements:


: Concomitant use is contraindicated due to the risk of additive toxicity. Herbs

containing hepatotoxic PAs include borage, butterbur, coltsfoot, comfrey, gravel

root, hemp agrimony, hound's tongue, and the Senecio species plants dusty

miller, alpine ragwort, groundsel, golden ragwort, and tansy ragwort (2).




Interactions with Drugs:

None known.

Interactions with Foods:

None known.

Interactions with Lab Tests:

None known.

Interactions with Diseases or Conditions:

CROSS-ALLERGENICITY: Boneset can cause an allergic reaction in individuals

sensitive to the Asteraceae/Compositae family. Members of this family include

ragweed, chrysanthemums, marigolds, daisies, and many other herbs.


ORAL: Traditionally one cup of tea, prepared by steeping 1-2 grams herb in 150

mL boiling water, has been used three times daily. The liquid extract, 1:1 in 25%

alcohol, has been used 1-2 mL three times daily. 1-4 mL of the tincture, 1:5 in

45% alcohol, has also been used three times daily (1).

Specific References: THYME

1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare
Professionals. London, UK: The Pharmaceutical Press, 1996.

2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine
alkaloids. J Hepatol 2003;39:437-46.

3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie

4. Habtemariam S, Macpherson AM. Cytotoxicity and antibacterial activity

of ethanol extract from leaves of a herbal drug, boneset (Eupatorium

perfoliatum). Phytother Res 2000;14:575-7.

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